Abstract
A novel (4,5-dihydroimidazol-2-yl)-biphenylamine series of 5-HT(7) agonist compounds was developed from a structurally related lead compound 1. The newly discovered series is exemplified by compound 2 that possesses high affinity for 5-HT(7) receptors and shows intrinsic agonist activity in functional assays. This new series has significant alpha(1) and alpha(2) activities perhaps due to the presence of the 2-aminoimidazoline moiety.
MeSH terms
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Aminobiphenyl Compounds / chemical synthesis*
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Aminobiphenyl Compounds / pharmacology*
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Animals
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Blood Pressure / drug effects
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Drug Evaluation, Preclinical
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Imidazoles / chemical synthesis*
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Imidazoles / pharmacology*
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In Vitro Techniques
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Indicators and Reagents
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Rats
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Receptors, Serotonin / drug effects*
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Serotonin Receptor Agonists / chemical synthesis*
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Serotonin Receptor Agonists / pharmacology*
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Spectrophotometry, Infrared
Substances
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Aminobiphenyl Compounds
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Imidazoles
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Indicators and Reagents
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Receptors, Serotonin
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Serotonin Receptor Agonists
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serotonin 7 receptor